Short Reports

Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation



The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZDand its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin.


FrizzledFrizzled-4carboxy-terminushelix VIIIDishevelledNorrin
  • Year: 2016
  • Volume: 11
  • Page/Article: 1
  • DOI: 10.5334/1750-2187-11-1
  • Published on 5 Feb 2016
  • Peer Reviewed