Research Articles

ER Stress Activates the TOR Pathway through Atf6



Cellular signaling pathways are often interconnected. They accurately and efficiently regulate essential cell functions such as protein synthesis, cell growth, and survival. The target of rapamycin (TOR) signaling pathway and the endoplasmic reticulum (ER) stress response pathway regulate similar cellular processes. However, the crosstalk between them has not been appreciated until recently and the detailed mechanisms remain unclear. Here, we show that ER stress-inducing drugs activate the TOR signaling pathway in S2R+ Drosophila cells. Activating transcription factor 6 (Atf6), a major stress-responsive ER transmembrane protein, is responsible for ER stress-induced TOR activation. Supporting the finding, we further show that knocking down of both site-1/2 proteases (S1P/S2P), Atf6 processing enzymes, are necessary to connect the two pathways.


ER stressTOR pathwayAtf6
  • Year: 2018
  • Volume: 13
  • Page/Article: 1
  • DOI: 10.5334/1750-2187-13-1
  • Submitted on 24 Feb 2017
  • Accepted on 26 Jan 2018
  • Published on 23 Apr 2018
  • Peer Reviewed